The scientific revolution of superantibiotics to fight superbacteria

The scientific revolution of superantibiotics to fight superbacteria
The scientific revolution of superantibiotics to fight superbacteria

If bacteria become totally resistant to antibiotics, a simple wound, a cut, could end in the death of a person because if a bacteria enters, there would be no way to eliminate it from the human body.

Now, two laboratories say they have found a drug that is “disorienting” bacteria. At the moment, it is very effective and has no resistance. This gives the world of biomedicine the alternative of gaining time in the very difficult and fundamental battle against bacteria.

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Alexander Fleming, discoverer of penincillin. The father of antibiotics. (Photo: A24.com)

A successful tool against “superbugs”

The use of antibiotics has gone in the opposite direction to what was recommended Fleming. It has been used more than necessary and poorly. Especially when, due to another scourge, self-medication, a person takes an antibiotic (the most common is amoxicillin) without really knowing what health problem they have. If it is something caused by a virus, antibiotics are totally useless.

But for the bacteriait is an opportunity to “learn and train” in his fight to make a living being sick. They recognize that drug and develop a way to become immune to it. So when it is really necessary to prescribe an antibiotic, it will be sterile: the bacteria will be completely immune and continue the infection process.

Now, Pfizer together with Abbvietwo North American laboratories developed a new antibiotic that at least appears to be an effective barrier against infections. “superbacteria”. While biochemistry continues the development of better and more efficient antibiotics against the clock.

Is called “Emblaveo” and it is actually a new drug thanks to the combination of two molecules already on the market. It is, in reality, a new medicine formed by the combination of two molecules already present on the market. Is about “aztreonam” and “avibactam”. One of the serious public health problems is hospital-acquired diseases that occur precisely because there are antibiotics that are no longer effective against certain bacteria.

The bacteria act on enzymes which are classified into four types, of the “A” to “D”. The two laboratories made a hopeful finding. He “avibactam” It is an inhibitor of some of these enzymes, but it does not work against “B.” There the bacteria finds the “fertile field” to develop infection.

So, with the merger of the “aztreonam”the new drug protects against these 4 types of enzymes. In treatments, it has already demonstrated its efficiency as an antibiotic for a certain group of patients, without the resistance of bacteria.

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The problem of “broad spectrum” antibiotics

As bacteria have become more and more resistant, WHO began to warn about this serious danger for human beings. If we continue down this path, he estimates that by 2050, the “superbacteria” They will be responsible for the deaths of 10,000,000 people per year.

That is why in hospitals, broad-spectrum antibiotics are applied to treat a patient until it is determined which bacteria is infecting. Or when the patient does not respond as expected. But this procedure also helps the bacteria, by replicating, develop a greater capacity for resistance.

That’s why advances like this are so important. Applying the appropriate antibiotic avoids using others that are not necessary and only “feed” the bacteria’s information.

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The health paradox for the development of antibiotics

In recent years, many laboratories have given up researching certain drugs. Why invest a lot of money in a product that, finally, will be applied in specific cases. The cost-benefit equation was not profitable. But this policy favored applying broad-spectrum antibiotics instead of specific ones, increased the power of “superbugs.”

Fortunately, that path is being retraced. Researching to produce the right drug is better, it does not favor bacteria and saves time in biomedical research.

If new infections are avoided as much as possible – with drugs or new vaccines – this saves time and reduces the use of antibiotics. Therefore, if each infection is treated with the appropriate remedy, the development of resistance of “superbugs” is slowed down.

By repeating this virtuous circle, biomedicine will be able to advance to continue improving the quality of life of human beings. In short, seriously apply the words of the father of antibiotics, Alexander Fleming.

 
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