Researchers found that lifestyle interventions, such as diet and exercise, resulted in a loss of weight average of 7.4%, but this weight was generally recovered within a period of 4.1 years.
On the other hand, the GLP-1 receptor agonists and the metabolic surgery and bariatric showed significantly superior results. The studies included thousands of patients from clinical studies and several randomized clinical trials.
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The discovery showed that diets are not as effective.
The discovery about weight loss
The results showed that five months of weekly injections of semaglutide, a GLP-1 receptor agonist, resulted in a loss of weight of 10.6%. Nine months of treatment with tirzepatide, another agonist, produced a loss of weight of 21.1%.
However, when treatment is stopped, approximately half of the weight lost was recovered within a year, regardless of the drug used. If injections were continued, patients treated with tirzepatide reached a plateau of blood loss. weight 22.5% at 17-18 months, while patients with semaglutide reached 14.9% in the same period.
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Surgery is the best method to lose weight and keep it off.
Metabolic and bariatric surgery procedures, such as gastric bypass and sleeve gastrectomy, demonstrated a complete loss of weight 31.9% and 29.5% one year after surgery, respectively.
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Furthermore, there was a loss of weight of approximately 25% for up to 10 years after the operation. This underscores the durability and superior effectiveness of these surgical procedures compared to other treatment options.
