Researchers from the Polytechnic University of Tomsk, in Russia, in collaboration with various research institutes in the country, developed an innovative technology based on nanoparticles, which uses the olfactory nerve path to carrying the drugs directly to brain tumors, such as glioblastoma. The information was disclosed in the
Official website of the Ministry of Science and Education of Russia.
Innovation takes advantage of the natural capacity of nanoparticles to cross the nasal cavity to the brain, a path already known for allowing the entry of viruses and toxic substances. This approach allows to overcome the blood brain barrier (BHE), which regulates the transport of substances between the blood and the central nervous system, which allows medications to be supplied directly to the brain, thus reducing the need for high doses and side effects.
In the tests an acetophenone spray was used to stimulate olfactory receptors and accelerate the supply of manganese particles directly to tumor cells. The results showed that manganese particles are located precisely in the tumor, without disperse by the brain, offering new possibilities for the directed treatment of glioblastoma, a disease with a 96 %mortality rate.
-In addition, this technology can be applied in the treatment of other brain diseases, such as Parkinson, dementia and depression.
The method, which has demonstrated efficacy in preliminary clinical trials, promises a significant advance in the development of more effective therapies for brain diseases.
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