Concern for the link between Atopic Dermatitis (DA) and the Attention deficit and hyperactivity disorder (ADHD) It has been increasing, given the significant impact of both conditions on the quality of life of those who suffer from them. It gives, characterized by being a Chronic skin inflammatory diseasehas been linked to an increased risk of developing Neuropsychiatric problemsincluding ADHD.
The main objective of this meta -analysis, conducted by researchers from the University of Chinese Medicine in Zhejiang, was to elucidate the bidirectional relationship between the DA and ADHD, exploring specific subgroups and potential modifiers.
An exhaustive search in databases was carried out until March 11, 2024. Observational studies were included that reported both conditions as exposure or result variables.
After a selection process, 49 studies were included that covered a total of 7,118,647 individuals with DA and 2,233,275 with ADHD. Patients with DA showed more likely to present ADHD (OR = 1.34; 95%CI: 1.25-1.44; p <0.01), and the same was observed in the reverse sense (or = 1.45; 95%IC: 1.21-1.73; p <0.01). Subgroup analysis evidenced more pronounced associations in studies that included patients with severe atopic dermatitis (OR = 2.62; 95%CI: 1.76-3.92; p <0.01), multiple allergic comorbilities (or = 2.89; 95%IC: 1.18-7.10; p <0.01) Sleep disorders (OR= 2,43; IC 95%: 2,14-2,76; p<0,01).
These findings corroborate a significant bidirectional association between atopic dermatitis and ADHD, suggesting that both conditions can act as independent risk factors and enhance each other. This highlights the need for greater awareness and early interventions, especially in people who present severe manifestations of DA, sleep problems and Multiple allergic diseases.
